Disease-modifying therapies

Disease-modifying therapies

Despite significant advancements in insulin therapy and glucose monitoring, managing type 1 diabetes remains challenging, and therapeutic options are limited. There is an urgent need for disease-modifying therapies that target the autoimmune root of the disease to prevent, delay, or modify its disease course. Such strategies have the potential to significantly improve both quality of life and long-term health outcomes for individuals living with type 1 diabetes.

Disease-modifying therapies projects

1/1/2025
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12/31/2028
Age-related heterogeneity in response to disease-modifying therapies in new-onset type 1 diabetes

Promotors:

Chantal Mathieu

Conny Gysemans

Pierre Lemaitre

10/1/2024
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9/30/2030
Personalized precision medicine for the prevention and reversal of type 1 diabetes: a stepwise approach

Promotors:

Chantal Mathieu

Conny Gysemans

Kristina Casteels

Lut Overbergh

Pierre Lemaitre

8/7/2022
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8/7/2026
Characterization of the dynamic immunophenotype during type 1 diabetes progression to identify predictive biomarkers of anti-CD3 mono- and combination therapy in disease prevention and reversal in mice

Promotors:

Chantal Mathieu

Conny Gysemans

Amber Wouters

8/1/2019
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5/31/2023
Novel immunotherapies to prevent or arrest type 1 diabetes

Promotors:

Chantal Mathieu

Conny Gysemans

Pieter-Jan Martens

9/1/2014
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12/6/2019
A novel L. lactis-based antigen-specific platform for the treatment of type 1 diabetes: essential steps towards successful clinical translation.

Promotors:

Chantal Mathieu

Dana Cook

1/1/2013
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12/31/2016
Optimizing antigen-specific immunotherapy in type 1 diabetes.

Promotors:

Chantal Mathieu

Conny Gysemans

Hannelie Korf

6/1/2012
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12/22/2016
Boosting beta-cell function for treatment of type 1 diabetes.

Promotors:

Chantal Mathieu

Conny Gysemans

João Paulo Monteiro Carvalho Mori Cunha

10/1/2009
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9/16/2013
Novel immunotherapies in type 1 diabetes: exploring antigen-specific and non-specific approaches.

Promotors:

Chantal Mathieu

Conny Gysemans

Tatiana Takiishi

9/1/2008
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7/17/2014
ActoBiotics for antigen-specific intervention in type 1 diabetes: mono- and combination therapy.

Promotors:

Chantal Mathieu

Conny Gysemans

Sofie Robert

Support us

Choose to make a direct impact by contributing to a specific research project or by supporting the overarching goals of the Hippo & Friends Type 1 Diabetes Fund. 

By donating today, you enable early-career scientists to pursue groundbreaking research aimed at preventing and curing type 1 diabetes.
Every contribution moves us one step closer to breakthroughs that matter.