Beta cells

Beta cells

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Beta-cell stress plays a pivotal role in triggering the autoimmune response in type 1 diabetes, positioning them not merely as passive targets but as active participants in their own destruction. The persistence of beta-cell loss, even with immune-modulating therapies, underscores the involvement of non-immune factors in disease progression. This insight emphasizes the urgent need for therapies that simultaneously enhance beta-cell resilience and modulate immune responses, aiming to prevent—and potentially reverse—beta-cell destruction.

Beta cell projects

Overview of all projects
9/1/2022
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8/31/2024
SyneRegIm: exploring the SYNErgistic effect of β-cell REGeneration and emerging IMmune intervention strategies to prevent and/or reverse type 1 diabetes.

Promotors:

Chantal Mathieu

Conny Gysemans

1/1/2020
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10/31/2025
Citrullinated and deamidated neo-epitopes and their role in murine type 1 diabetes.

Promotors:

Chantal Mathieu

Lut Overbergh

Ylke Bruggeman

10/1/2018
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8/31/2020
Citrullinated beta-cell proteins: a driving force behind type 1 diabetes?

Promotors:

Chantal Mathieu

Mijke Buitinga

10/1/2018
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9/30/2024
The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators.

Promotors:

Chantal Mathieu

Conny Gysemans

Lut Overbergh

Annemieke Verstuyf

3/1/2018
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2/28/2021
Role of citrullination in the generation of autoantigens in type 1 diabetes.

Promotors:

Chantal Mathieu

Lut Overbergh

9/1/2017
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7/1/2022
Post-translational modification of GRP78 and its role in human type 1 diabetes.

Promotors:

Chantal Mathieu

Lut Overbergh

Mijke Buitinga

Aïsha Callebaut

7/30/2017
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4/20/2018
Assessing the relevance of a target organ-specific microRNA signature in type 1 diabetes.

Promotors:

Chantal Mathieu

Giuliana Ventriglia

3/1/2017
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2/29/2020
The dialogue between the beta-cell and the immune system in type 1 diabetes: role of glucose-regulated protein 78 in human beta-cells

Promotors:

Chantal Mathieu

Saurabh Vig

9/21/2015
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6/29/2021
The role of the post-translational modification citrullination in type 1 diabetes.

Promotors:

Chantal Mathieu

Lut Overbergh

Mijke Buitinga

Fernanda Marques Camara Sodre

10/1/2013
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9/30/2018
The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators.

Promotors:

Chantal Mathieu

Roger Bouillon

Mark Waer

Frans Schuit

Annemieke Verstuyf

9/1/2012
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2/21/2017
The beta-cell in type 1 diabetes: interaction with the immune system.

Promotors:

Chantal Mathieu

Lut Overbergh

Inne Crèvecoeur

10/1/2011
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9/30/2014
The beta-cell in the pathogenesis of type 1 diabetes: focus on translational and post-translational events.

Promotors:

Chantal Mathieu

Wannes D'Hertog

10/1/2009
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3/10/2016
Dynamic interaction between beta cells, antigens and immune system cells in type 1 diabetes.

Promotors:

Chantal Mathieu

Hannelie Korf

1/1/2008
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12/31/2011
Protecting the beta-cell in type 1 diabetes mellitus through better understanding of the intracellular signaling cascades: interventions in preclinical models.

Promotors:

Chantal Mathieu

Conny Gysemans

Support us

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By donating today, you enable early-career scientists to pursue groundbreaking research aimed at preventing and curing type 1 diabetes.
Every contribution moves us one step closer to breakthroughs that matter.

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