Publications

Conny Gysemans, Mateson Beya, Erika Pedace, Chantal Mathieu. Exploring Neutrophil Heterogeneity and Plasticity in Health and Disease. Biomedicines. 2025 13(3):597.

Robert Moulder, M Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L Elo, Riitta Lahesmaa; INNODIA consortium. Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease. Diabetologia. 2025 ahead of print

Luisa Hoffmann, Mirjam Kohls, Stefanie Arnolds, Peter Achenbach, Regine Bergholdt, Ezio Bonifacio, Emanuele Bosi, Melanie Gündert, Bianca K Hoefelschweiger, Sandra Hummel, Przemysława Jarosz-Chobot, Olga Kordonouri, Vito Lampasona, Parth Narendran, Lut Overbergh, Flemming Pociot, João Filipe Raposo, Zdeněk Šumník, Agnieszka Szypowska, Jurgen Vercauteren, Christiane Winkler, Chantal Mathieu, Anette-Gabriele Ziegler, the EDENT1FI consortium. EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents. BMJ Open. 2025 15(1):e088522

Roberto Mallone, Emily Sims, Peter Achenbach, Chantal Mathieu, Alberto Pugliese, Mark Atkinson, Sanjoy Dutta, Carmella Evans-Molina, David Klatzmann, Anne Koralova, S Alice Long, Lut Overbergh, Teresa Rodriguez-Calvo, Anette-Gabriele Ziegler, Sylvaine You. Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future. Diabetes. 2025 74(1):12-21

Pierre Lemaitre, Chantal Mathieu, Conny Gysemans. Protocol for murine multi-tissue deep immunophenotyping using a 40-color full-spectrum flow cytometry panel. STAR Protoc. 2024 (4):103492

Chantal Mathieu. Disease modifying therapies in diabetes and endocrinology. Lancet Diabetes Endocrinol. 2024 12(12):876-877.

Julie Wych, Martina Brunner, Rachel Stenson, Piotr Jaroslaw Chmura, Thomas Danne, Adrian Paul Mander, Chantal Mathieu, Colin Dayan, Thomas R Pieber. Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. BMJ Open. 2024 14(11):e091597

Tommi Vatanen, Carine de Beaufort, M Loredana Marcovecchio, Lut Overbergh, Soren Brunak, Mark Peakman, Chantal Mathieu, Mikael Knip; INNODIA consortium. Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study. Diabetologia. 2024 67(9):1930-1942.

Stefanie Doms, Lieve Verlinden, Iris Janssens, Justine Vanhevel, Roy Eerlings, René Houtman, Shigeaki Kato, Chantal Mathieu, Brigitte Decallonne, Geert Carmeliet, Annemieke Verstuyf. Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose. Bone Res. 2024 12(1):44.

Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine F A Bruggraber, M Loredana Marcovecchio, Emile Hendricks, Naba Al-Sari, Ismo Mattila, Cristina Legido-Quigley, Tommi Suvitaival, Piotr J Chmura, Mikael Knip, Anke M Schulte, Jeong Heon Lee, Guido Sebastiani, Giuseppina Emanuela Grieco, Laura L Elo, Simranjeet Kaur, Flemming Pociot, Francesco Dotta, Tim Tree, Riitta Lahesmaa, Lut Overbergh, Chantal Mathieu, Mark Peakman, Søren Brunak; INNODIA investigators. Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study. Diabetes Metab Res Rev. 40(5):e3833.

Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Elena Aiello, Laura Nigi, Caterina Formichi, Juan Fernandez-Tajes, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu, Francesco Dotta; INNODIA investigators. A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes. Cell Rep Med. 5(6):101591.

M Loredana Marcovecchio, A Emile J Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A Todd, Bart Van der Schueren, Linda S Wicker, Mark Peakman, Chantal Mathieu; INNODIA consortium. The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults. Diabetologia. 2024 67(6):995-1008.

Aïsha Callebaut, Perrin Guyer, Rocky L Baker, Joylynn B Gallegos, Anita C Hohenstein, Peter A Gottlieb, Chantal Mathieu, Lut Overbergh, Kathryn Haskins, Eddie A James. An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes. Diabetes. 2024 73(5):743-750.

Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L Eizirik, Sally C Kent, Chantal Mathieu, Eddie A James, Lut Overbergh. CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets. Diabetes. 2024 73(5):728-742.

Pieter-Jan Martens, Chantal Mathieu. Type 1 diabetes mellitus: a brave new world. Nat Rev Endocrinol. 2024 20(2):71-72.

A Emile J Hendriks, M Loredana Marcovecchio, Rachel E J Besser, Ezio Bonifacio, Kristina Casteels, Helena Elding Larsson, Gita Gemulla, Markus Lundgren, Olga Kordonouri, Roberto Mallone, Flemming Pociot, Agnieszka Szypowska, Jorma Toppari, Thekla von dem Berge, Anette G Ziegler, Chantal Mathieu, Peter Achenbach; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Clinical care advice for monitoring of islet autoantibody-positive individuals with presymptomatic type 1 diabetes. Diabetes Metab Res Rev. 2024 40(2):e3777.

Chantal Mathieu, Alice Wiedeman, Karen Cerosaletti, S Alice Long, Elisavet Serti, Laura Cooney, Joan Vermeiren, Silvia Caluwaerts, Karolien Van Huynegem, Lothar Steidler, Sven Blomme, Pieter Rottiers, Gerald T Nepom, Kevan C Herold; AG019-T1D-101 Trial Investigators. A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab. Diabetologia. 2024 67(1):27-41.

Valerie Vandenbempt, Sema Elif Esk, Manoja K Brahma, Ao Li, Javier Negueruela, Ylke Bruggeman, Stéphane Demine, Peng Xiao, Alessandra K Cardozo, Nicolas Baeyens, Luciano G Martelotto, Sumeet Pal Singh, Eliana Mariño, Conny Gysemans, Esteban N Gurzov. HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes. iScience. 2023 27(1):108694.

Ylke Bruggeman, Pieter-Jan Martens, Gabriele Sassi, Marijke Viaene, Clive H Wasserfall, Chantal Mathieu, Conny Gysemans. Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development. Front Endocrinol (Lausanne). 2023 14:1275316.

Robert Moulder, Tommi Välikangas, M Karoliina Hirvonen, Tomi Suomi, Caroline A Brorsson, Niina Lietzén, Sylvaine F A Bruggraber, Lut Overbergh, David B Dunger, Mark Peakman, Piotr J Chmura, Soren Brunak, Anke M Schulte, Chantal Mathieu, Mikael Knip, Laura L Elo, Riitta Lahesmaa; INNODIA consortium. Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory. Diabetologia. 2023 66(11):1983-1996.

Mark A Atkinson, Michael J Haller, Desmond A Schatz, Manuela Battaglia, Chantal Mathieu. Time for changes in type 1 diabetes intervention trial designs. Lancet Diabetes Endocrinol. 2023 11(11):789-791.

Jamie L Felton, Kurt J Griffin, Richard A Oram, Cate Speake, S Alice Long, Suna Onengut-Gumuscu, Stephen S Rich, Gabriela S F Monaco, Carmella Evans-Molina, Linda A DiMeglio, Heba M Ismail, Andrea K Steck, Dana Dabelea, Randi K Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M Wentworth, Maria J Redondo, Emily K Sims; ADA/EASD PMDI. Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review. Commun Med (Lond). 2023 3(1):130.

Gabriele Sassi, Giada Licata, Giuliana Ventriglia, Amber Wouters, Pierre Lemaitre, Ruth Seurinck, Alessia Mori, Giuseppina Emanuela Grieco, Samal Bissenova, Darcy Ellis, Silvia Caluwaerts, Pieter Rottiers, Niels Vandamme, Chantal Mathieu, Francesco Dotta, Conny Gysemans, Guido Sebastiani. A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis-Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes. Diabetes. 2023 72(10):1470-1482

Samal Bissenova, Mijke Buitinga, Markus Boesch, Hannelie Korf, Kristina Casteels, An Teunkens, Chantal Mathieu, Conny Gysemans. High-Throughput Analysis of Neutrophil Extracellular Trap Levels in Subtypes of People with Type 1 Diabetes. Biology (Basel). 2023 12(6):882.

Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L Elo; INNODIA Consortium. Gene expression signature predicts rate of type 1 diabetes progression. EBioMedicine. 2023 92:104625.

Samal Bissenova, Darcy Ellis, Aïsha Callebaut, Guy Eelen, Rita Derua, Mijke Buitinga, Chantal Mathieu, Conny Gysemans, Lut Overbergh. NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins. Cells. 2023 12(9):1319.

Samal Bissenova, Darcy Ellis, Chantal Mathieu, Conny Gysemans. Neutrophils in autoimmunity: when the hero becomes the villain. Clin Exp Immunol. 2022 210(2):128-140.

Pieter-Jan Martens, Darcy Ellis, Ylke Bruggeman, Marijke Viaene, Jos Laureys, Luc Teyton, Chantal Mathieu, Conny Gysemans. Preventing type 1 diabetes in late-stage pre-diabetic NOD mice with insulin: A central role for alum as adjuvant.Front Endocrinol (Lausanne). 2022 13:1023264.

Kailash Singh, Orian Bricard, Jeason Haughton, Mikaela Björkqvist, Moa Thorstensson, Zhengkang Luo, Loriana Mascali, Emanuela Pasciuto, Chantal Mathieu, James Dooley, Adrian Liston. Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development. Biomolecules . 2022 12(10):1493.

Aїsha Callebaut, Ylke Bruggeman, Cloé Zamit, Fernanda Marques Câmara Sodré, Magali Irla, Chantal Mathieu, Mijke Buitinga, Lut Overbergh. Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation. Front Endocrinol (Lausanne). 2022 13:908248.

Pieter-Jan Martens, Javier Centelles-Lodeiro, Darcy Ellis, Dana Paulina Cook, Gabriele Sassi, Lieve Verlinden, Annemieke Verstuyf, Jeroen Raes, Chantal Mathieu, Conny Gysemans. High Serum Vitamin D Concentrations, Induced via Diet, Trigger Immune and Intestinal Microbiota Alterations Leading to Type 1 Diabetes Protection in NOD Mice. Front Immunol. 2022 13:902678.

David B Dunger, Sylvaine F A Bruggraber, Adrian P Mander, M Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M Schulte, Chantal Mathieu; INNODIA consortium. INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes. Trials. 2022 23(1):414.

Bernat Elvira, Valerie Vandenbempt, Julia Bauzá-Martinez, Raphaël Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L Winder, Manoja K Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N Gurzov. PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes. Diabetes. 2022 71(4):653-668.

Shweta Saini, An-Sofie Vanherwegen, Sayuan Liang, Rein Verbeke, Hannelie Korf, Ine Lentacker, Stefaan C De Smedt, Conny Gysemans, Uwe Himmelreich. Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation. Mol Imaging Biol. 2022 24(2):321-332.

Emily K Sims, Rachel E J Besser, Colin Dayan, Cristy Geno Rasmussen, Carla Greenbaum, Kurt J Griffin, William Hagopian, Mikael Knip, Anna E Long, Frank Martin, Chantal Mathieu, Marian Rewers, Andrea K Steck, John M Wentworth, Stephen S Rich, Olga Kordonouri, Anette-Gabriele Ziegler, Kevan C Herold; NIDDK Type 1 Diabetes TrialNet Study Group. Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective. Diabetes. 2022 71(4):610-623.

Jef Serré, Ajime Tom Tanjeko, Carolien Mathyssen, Tobias Heigl, Annelore Sacreas, Dana Paulina Cook, Erik Verbeken, Karen Maes, Jan Verhaegen, Charles Pilette, Jeroen Vanoirbeek, Conny Gysemans, Chantal Mathieu, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez. Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice. Respir Res. 2022 23(1):40.

Xenia Geeraerts, Juan Fernández-Garcia, Felix J Hartmann, Kyra E de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C Bendall, Damya Laoui, Jan Van den Bossche, Sarah-Maria Fendt, Jo A Van Ginderachter. Macrophages are metabolically heterogeneous within the tumor microenvironment. Cell Rep . 2021 37(13):110171.

Charlotte S Wilhelm-Benartzi, Sarah E Miller, Sylvaine Bruggraber, Diane Picton, Mark Wilson, Katrina Gatley, Anita Chhabra, M Loredana Marcovecchio, A Emile J Hendriks, Hilde Morobé, Piotr Jaroslaw Chmura, Simon Bond, Bärbel Aschemeier-Fuchs, Mikael Knip, Timothy Tree, Lut Overbergh, Jaivier Pall, Olivier Arnaud, Michael J Haller, Almut Nitsche, Anke M Schulte, Chantal Mathieu, Adrian Mander, David Dunger. Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes. BMJ Open. 2021 11(12):e053669.

Chantal Mathieu, Pieter-Jan Martens, Roman Vangoitsenhoven. One hunderd years of insulin therapy. Nat Rev Endocrinol. 2021 17(12):715-725.

Marie Eliane Azoury, Fatoumata Samassa, Mijke Buitinga, Laura Nigi, Noemi Brusco, Aïsha Callebaut, Matthieu Giraud, Magali Irla, Ana Ines Lalanne, Alexia Carré, Georgia Afonso, Zhicheng Zhou, Barbara Brandao, Maikel L Colli, Guido Sebastiani, Francesco Dotta, Maki Nakayama, Decio L Eizirik, Sylvaine You, Sheena Pinto, Mark J Mamula, Yann Verdier, Joelle Vinh, Soren Buus, Chantal Mathieu, Lut Overbergh, Roberto Mallone. CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes. Diabetes. 2021 70(12):2879-2891.

Bart O Roep, Enrique Montero, René van Tienhoven, Mark A Atkinson, Desmond A Schatz, Chantal Mathieu. Defining a cure for type 1 diabetes: a call to action. Lancet Diabetes Endocrinol. 2021 9(9):553-555.

Giuseppina E Grieco, Guido Sebastiani, Daniela Fignani, Noemi Brusco, Laura Nigi, Caterina Formichi, Giada Licata, Marco Bruttini, Romina D'Aurizio, Chantal Mathieu, Conny Gysemans, Francesco Dotta. Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples. STAR Protoc. 2021 2(3):100606.

Pieter-Jan Martens, Conny Gysemans, Chantal Mathieu. 100 YEARS OF INSULIN: Arresting or curing type 1 diabetes: an elusive goal, but closing the gap. J Endocrinol. 2021 249(2):T1-T11.

Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi, Julie Messiaen, Asier Antoranz, Johnny Duerinck, Daliya Kancheva, Liesbet Martens, Karen De Vlaminck, Hannah Van Hove, Signe Schmidt Kjølner Hansen, Francesca Maria Bosisio, Koen Van der Borght, Steven De Vleeschouwer, Raf Sciot, Luc Bouwens, Michiel Verfaillie, Niels Vandamme, Roosmarijn E Vandenbroucke, Olivier De Wever, Yvan Saeys, Martin Guilliams, Conny Gysemans, Bart Neyns, Frederik De Smet, Diether Lambrechts, Jo A Van Ginderachter, Kiavash Movahedi. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nat Neurosci. 2021 24(4):595-610.

Matthias von Herrath, Stephen C Bain, Bruce Bode, Jesper Ole Clausen, Ken Coppieters, Leylya Gaysina, Janusz Gumprecht, Troels Krarup Hansen, Chantal Mathieu, Cristobal Morales, Ofri Mosenzon, Stine Segel, George Tsoukas, Thomas R Pieber; Anti-IL-21–liraglutide Study Group investigators and contributors. Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2021 9(4):212-224.

Ylke Bruggeman, Fernanda M C Sodré, Mijke Buitinga, Chantal Mathieu, Lut Overbergh, Maria J L Kracht. Targeting citrullination in autoimmunity: insights learned from preclinical mouse models. Expert Opin Ther Targets. 2021 25(4):269-281.

Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli, Miriam Cnop, Decio L Eizirik, Piero Marchetti, Lorella Marselli. Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis. Biomolecules. 2021 11(2):320.

Aïsha Callebaut, Rita Derua, Saurabh Vig, Thomas Delong, Chantal Mathieu, Lut Overbergh. Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra. J Proteome Res. 2021 20(2):1405-1414.

Bart Keymeulen, André van Maurik, Dave Inman, João Oliveira, Rene McLaughlin, Rachel M Gittelman, Bart O Roep, Pieter Gillard, Robert Hilbrands, Frans Gorus, Chantal Mathieu, Ursule Van de Velde, Nicolas Wisniacki, Antonella Napolitano. A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes. Diabetologia. 2021 64(2):313-324.

Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L Colli, Piero Marchetti, Chantal Mathieu, Decio L Eizirik, Guido Sebastiani, Francesco Dotta. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature. Front Endocrinol (Lausanne). 2020 11:596898.