PhD Defence Gabriele Sassi

November 7, 2023
Congratulations to Gabriele Sassi, now better known as Dr. Sassi, for defending this PhD thesis entitled 'Multi-omics technologies to identify biomarkers for therapy prediction and response in type 1 diabetes.' We thank the jury members Alice Long (Benaroya Research Institute, Virginia Mason Medical Center, Seattle, USA), Jo Van Ginderachter (Vrije Universiteit Brussel (VUB), Brussels, Belgium), Ben Sprangers (Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium), and Thierry Voet (KU Leuven, Leuven, Belgium) for the interesting discussions regarding his thesis subject.
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This PhD project aimed to use deep sequencing of single-cell RNAs to identify the unique gene expression profiles and heterogeneities in islet-derived white blood cells during autoimmune type 1 diabetes progression but also from therapeutic responders and non-responders. Moreover, he wanted to correlate these tissue-specific immune signatures with circulating (cell-free plasma) small non-coding RNAs during disease progression and in responders and non-responders pre- and post-therapy to identify potential markers for disease staging, prognosis, and therapy prediction.

The full text can be found via this link.

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