PhD Defence Gabriele Sassi

November 7, 2023
Congratulations to Gabriele Sassi, now better known as Dr. Sassi, for defending this PhD thesis entitled 'Multi-omics technologies to identify biomarkers for therapy prediction and response in type 1 diabetes.' We thank the jury members Alice Long (Benaroya Research Institute, Virginia Mason Medical Center, Seattle, USA), Jo Van Ginderachter (Myeloid Cell Immunology Lab (MCI), Vrije Universiteit Brussel (VUB), Brussels, Belgium), Ben Sprangers (Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium), and Thierry Voet (LISCO, KU Leuven, Leuven, Belgium) for the engaging discussions regarding his thesis subject.
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PhD Research Summary - Dr. Sassi

This project used single-cell RNA sequencing to uncover unique gene expression profiles and heterogeneity in islet-infiltrating immune cells during type 1 diabetes progression, as well as in therapeutic responders and non-responders. In parallel, circulating small non-coding RNAs were studied in plasma to link tissue-specific immune signatures with blood-based biomarkers.

Together, these approaches aim to identify novel markers for disease staging, prognosis, and therapy prediction, providing valuable insights into the mechanisms driving type 1 diabetes and treatment outcomes.

The full text can be found via this link.

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