
PhD Research Summary - Dr. Fernanda Sodré
Type 1 diabetes is caused by the immune system attacking and destroying the insulin-producing beta cells of the pancreas, but the exact trigger remains unclear. In her PhD, Fernanda Sodré investigated the role of citrullination, a post-translational modification of proteins mediated by PAD enzymes.
Her work demonstrated that citrullinated GRP78, previously identified as an autoantigen in non-obese diabetic (NOD) mice, is also an autoantigen in human type 1 diabetes. Importantly, blocking citrullination in NOD mice prevented diabetes development, and vaccination with a citrullinated GRP78 peptide reduced diabetes incidence.
These findings highlight citrullination as a key player in type 1 diabetes and open new perspectives for therapeutic intervention.
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