T cells
©Steve Gschmeissner / Science Photo Library
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Autoreactive T cells, particularly CD8+ cytotoxic T cells, are key drivers of the autoimmune response in type 1 diabetes, directly recognizing and destroying beta cells. CD4+ T cells intensify this assault by secreting pro-inflammatory cytokines. Compounding the problem, a disruption or imbalance in T regulatory (Treg) cell subsets, which typically suppress pathogenic T cells, may further promote disease development.
T-cell Projects
1/1/2019
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12/31/2022
Single cell RNA and small non-coding RNA sequencing to identify biomarkers for pathogenesis and therapy response in type 1 diabetes.
Promotors:
Chantal Mathieu
Conny Gysemans
11/19/2018
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11/7/2023
Multi-omics technologies to identify biomarkers for therapy prediction and response in type 1 diabetes.
Promotors:
Chantal Mathieu
Conny Gysemans
Gabriele Sassi
1/1/2015
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12/31/2017
Unraveling the mechanisms required to dampen autoreactive T cell reactivity following macrophage-apoptotic beta cell interaction
Promotors:
Chantal Mathieu
Hannelie Korf
10/1/2013
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9/30/2018
The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators.
Promotors:
Chantal Mathieu
Roger Bouillon
Mark Waer
Frans Schuit
Annemieke Verstuyf