Neutrophils

Neutrophils, a key component of the innate immune system, are believed to contribute to the inflammation and tissue damage seen in type 1 diabetes, though their exact role in disease onset and progression is still not fully understood. Recent studies suggest that neutrophils may interact with other immune cells, such as T cells, to amplify the autoimmune response against beta cells, but the mechanisms behind this interaction remain unclear. Key knowledge gaps include how neutrophils are activated in type 1 diabetes, their precise involvement in beta-cell destruction, and whether targeting neutrophil activity could offer therapeutic benefits in managing the disease.